:root{--fda-blue-50: #EBF5FF;--fda-blue-100: #BFDBFE;--fda-blue-200: #93C5FD;--fda-blue-300: #60A5FA;--fda-blue-400: #3B82F6;--fda-blue-500: #2563EB;--fda-blue-600: #1E40AF;--fda-blue-700: #1F3A5F;--fda-blue-800: #274B7A;--fda-blue-900: #0F2557;--fda-gray-50: #F9FAFB;--fda-gray-100: #F3F4F6;--fda-gray-200: #E5E7EB;--fda-gray-300: #D1D5DB;--fda-gray-400: #9CA3AF;--fda-gray-500: #6B7280;--fda-gray-600: #4B5563;--fda-gray-700: #374151;--fda-gray-800: #1F2937;--fda-gray-900: #1A1A1A;--fda-amber-50: #FEF3C7;--fda-amber-100: #FFF3E0;--fda-amber-400: #F59E0B;--fda-amber-700: #92400E;--fda-amber-800: #E65100;--fda-red-50: #FEE2E2;--fda-red-100: #FFEBEE;--fda-red-400: #EF4444;--fda-red-600: #DC2626;--fda-red-700: #C62828;--fda-green-400: #10B981;--fda-green-500: #059669;--fda-green-600: #2E7D32;--fda-green-50: #E8F5E9;--fda-purple-400: #8B5CF6;--fda-pink-400: #EC4899;--fda-white: #FFFFFF;--fda-space-1: .25rem;--fda-space-2: .5rem;--fda-space-3: .75rem;--fda-space-4: 1rem;--fda-space-5: 1.25rem;--fda-space-6: 1.5rem;--fda-space-8: 2rem;--fda-space-10: 2.5rem;--fda-space-12: 3rem;--fda-space-16: 4rem;--fda-text-xs: .6875rem;--fda-text-sm: .75rem;--fda-text-base: .8125rem;--fda-text-md: .875rem;--fda-text-lg: .9375rem;--fda-text-xl: 1rem;--fda-text-2xl: 1.125rem;--fda-text-3xl: 1.25rem;--fda-text-4xl: 1.5rem;--fda-text-5xl: 1.75rem;--fda-font-normal: 400;--fda-font-medium: 500;--fda-font-semibold: 600;--fda-font-bold: 700;--fda-radius-sm: 3px;--fda-radius-md: 4px;--fda-radius-lg: 5px;--fda-radius-xl: 8px;--fda-radius-full: 9999px;--fda-shadow-sm: 0 1px 3px rgba(0, 0, 0, .08);--fda-shadow-md: 0 4px 12px rgba(0, 0, 0, .1);--fda-shadow-lg: 0 8px 24px rgba(0, 0, 0, .12);--fda-duration-fast: .15s;--fda-duration-normal: .2s;--fda-duration-slow: .3s;--fda-ease: ease;--fda-surface-primary: var(--fda-white);--fda-surface-secondary: var(--fda-gray-50);--fda-surface-accent: #EEF3F9;--fda-surface-overlay: rgba(0, 0, 0, .5);--fda-text-primary: var(--fda-gray-900);--fda-text-secondary: #4A4A4A;--fda-text-tertiary: var(--fda-gray-500);--fda-text-inverse: var(--fda-white);--fda-text-link: var(--fda-blue-700);--fda-text-link-hover: var(--fda-blue-800);--fda-border-default: var(--fda-gray-200);--fda-border-accent: #D6E1EF;--fda-border-focus: var(--fda-blue-700);--fda-focus-ring: 0 0 0 3px rgba(31, 58, 95, .1);--fda-risk-red: var(--fda-red-400);--fda-risk-red-bg: var(--fda-red-50);--fda-risk-yellow: var(--fda-amber-400);--fda-risk-yellow-bg: var(--fda-amber-50);--fda-risk-green: var(--fda-green-500);--fda-risk-green-bg: var(--fda-green-50);--fda-risk-gray: var(--fda-gray-400);--fda-risk-gray-bg: var(--fda-gray-100);--fda-type-483: var(--fda-blue-400);--fda-type-483-bg: var(--fda-blue-50);--fda-type-483-text: #1565C0;--fda-type-wl: var(--fda-amber-400);--fda-type-wl-bg: var(--fda-amber-100);--fda-type-wl-text: var(--fda-amber-800);--fda-type-recall: var(--fda-red-400);--fda-type-recall-bg: var(--fda-red-100);--fda-type-recall-text: var(--fda-red-700);--fda-interactive-hover: var(--fda-surface-accent);--fda-interactive-active: var(--fda-blue-700);--fda-card-bg: var(--fda-surface-primary);--fda-card-border: var(--fda-border-default);--fda-card-radius: var(--fda-radius-lg);--fda-card-padding: var(--fda-space-5);--fda-card-shadow: var(--fda-shadow-sm);--fda-btn-bg: var(--fda-surface-primary);--fda-btn-border: var(--fda-border-default);--fda-btn-text: var(--fda-text-secondary);--fda-btn-radius: var(--fda-radius-lg);--fda-btn-padding-x: var(--fda-space-4);--fda-btn-padding-y: var(--fda-space-3);--fda-table-header-bg: var(--fda-surface-secondary);--fda-table-border: var(--fda-border-default);--fda-table-row-hover: var(--fda-surface-secondary);--fda-table-cell-padding: var(--fda-space-4);--fda-badge-radius: var(--fda-radius-md);--fda-badge-padding-x: var(--fda-space-3);--fda-badge-padding-y: var(--fda-space-1);--fda-badge-font-size: var(--fda-text-sm);--fda-badge-font-weight: 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h3{font-size:1.125rem;font-weight:600;margin-top:2rem;margin-bottom:.75rem}.prose ul,.prose ol{margin-bottom:1.5rem;padding-left:1.5rem}.prose li{margin-bottom:.5rem}.prose ul{list-style-type:disc;list-style-position:inside}.prose ol{list-style-type:decimal;list-style-position:inside}.prose strong{font-weight:600;color:var(--color-text-dark)}.prose em{font-style:italic}.prose blockquote,.gh-content blockquote,blockquote{background-color:var(--color-bg-light-blue);border-left:4px solid var(--color-primary);padding:1.25rem 1.5rem;margin:1.5rem 0;font-style:italic;color:var(--color-text-dark);border-radius:0 var(--radius) var(--radius) 0}.prose blockquote p,.gh-content blockquote p,blockquote p{margin-bottom:0;line-height:1.6}.prose h4,.gh-content h4{font-size:1.125rem;font-weight:600;margin-top:2rem;margin-bottom:.75rem;color:var(--color-text-dark)}.text-center{text-align:center}.text-uppercase{text-transform:uppercase;letter-spacing:.05em}.font-small{font-size:.875rem}.font-medium{font-size:1.125rem}.font-large{font-size:1.5rem}.color-secondary{color:var(--color-text-secondary)}.color-tertiary{color:var(--color-text-tertiary)}@media (max-width: 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var(--color-border)}.footer-container{max-width:var(--max-width);margin:0 auto;padding:3rem 1.5rem}.footer-columns{display:grid;grid-template-columns:1fr;gap:2rem;margin-bottom:2rem}@media (min-width: 768px){.footer-columns{grid-template-columns:repeat(4,1fr)}}.footer-column h3,.footer-column h4{font-weight:600;margin-bottom:1rem;color:var(--color-text-dark)}.footer-column h4{font-size:.875rem;text-transform:uppercase}.footer-column ul{list-style:none;padding:0;margin:0}.footer-column li{margin-bottom:.5rem}.footer-column a{color:var(--color-text-secondary);font-size:.875rem;text-decoration:none;transition:color var(--transition-fast)}.footer-column a:hover{color:var(--color-primary)}.footer-column p{color:var(--color-text-tertiary);font-size:.875rem;line-height:1.6;margin-bottom:0}.footer-bottom{padding-top:2rem;border-top:1px solid var(--color-border);display:flex;flex-direction:column;gap:1rem;align-items:center}@media (min-width: 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var(--fda-ease)}.fda-chart-card__export:hover{border-color:var(--fda-border-focus);color:var(--fda-text-link)}.fda-chart-card__body{width:100%;min-height:200px}.fda-chart-card__empty{display:flex;align-items:center;justify-content:center;height:100%;min-height:200px;color:var(--fda-text-tertiary);font-size:var(--fda-text-md)}.fda-pagination{display:flex;align-items:center;gap:var(--fda-space-2);flex-wrap:wrap;justify-content:center;padding:var(--fda-space-4) 0}.fda-pagination__btn,.fda-pagination__page{min-width:2.5rem;height:2.5rem;padding:var(--fda-space-2);border:1px solid var(--fda-border-default);background:var(--fda-surface-primary);color:var(--fda-text-primary);border-radius:var(--fda-radius-md);font-size:var(--fda-text-md);font-weight:var(--fda-font-medium);font-family:inherit;cursor:pointer;transition:all var(--fda-duration-normal) var(--fda-ease)}.fda-pagination__btn:hover:not(:disabled),.fda-pagination__page:hover:not(.is-active){background:var(--fda-surface-secondary);border-color:var(--fda-border-focus)}.fda-pagination__btn:disabled{opacity:.4;cursor:not-allowed}.fda-pagination__prev,.fda-pagination__next{padding:var(--fda-space-2) var(--fda-space-4)}.fda-pagination__page.is-active{background:var(--fda-interactive-active);color:var(--fda-text-inverse);border-color:var(--fda-interactive-active)}.fda-pagination__ellipsis{padding:var(--fda-space-2);color:var(--fda-text-secondary);font-weight:var(--fda-font-medium)}.fda-pagination__info{font-size:var(--fda-text-lg);color:var(--fda-text-secondary);margin-left:var(--fda-space-4)}@media (max-width: 768px){.fda-pagination{gap:var(--fda-space-1)}.fda-pagination__info{width:100%;text-align:center;margin-left:0}}.fda-data-table__container{overflow-x:auto;border:1px solid var(--fda-table-border);border-radius:var(--fda-card-radius)}.fda-data-table{width:100%;border-collapse:collapse;font-size:var(--fda-text-lg)}.fda-data-table thead{background:var(--fda-table-header-bg);border-bottom:2px solid var(--fda-table-border)}.fda-data-table__header{padding:var(--fda-table-cell-padding);text-align:left;font-weight:var(--fda-font-semibold);color:var(--fda-text-primary);white-space:nowrap}.fda-data-table--sortable{cursor:pointer;user-select:none;transition:color var(--fda-duration-normal) var(--fda-ease)}.fda-data-table--sortable:hover{color:var(--fda-text-link)}.fda-data-table--sortable:focus-visible{outline:2px solid var(--fda-border-focus);outline-offset:-2px}.fda-data-table--sorted-asc,.fda-data-table--sorted-desc{color:var(--fda-text-link)}.fda-data-table__sort-icon{display:inline-block;margin-left:var(--fda-space-1);font-size:var(--fda-text-sm);opacity:.6}.fda-data-table--sorted-asc .fda-data-table__sort-icon:after{content:"▲"}.fda-data-table--sorted-desc .fda-data-table__sort-icon:after{content:"▼"}.fda-data-table__cell{padding:var(--fda-table-cell-padding);border-bottom:1px solid var(--fda-table-border);vertical-align:top}.fda-data-table__row{transition:background var(--fda-duration-fast) var(--fda-ease);cursor:pointer}.fda-data-table__row:hover{background:var(--fda-table-row-hover)}.fda-data-table__row:last-child .fda-data-table__cell{border-bottom:none}.fda-data-table--expanded{background:var(--fda-surface-accent);border-left:3px solid var(--fda-text-link)}.fda-data-table__expanded-row td{padding:0;border-bottom:2px solid var(--fda-text-link)}.fda-data-table__empty{text-align:center;padding:var(--fda-space-16) var(--fda-space-8);color:var(--fda-text-secondary);font-size:var(--fda-text-2xl)}.fda-data-table--compact .fda-data-table__header,.fda-data-table--compact .fda-data-table__cell{padding:var(--fda-space-2) var(--fda-space-3);font-size:var(--fda-text-md)}@media (max-width: 768px){.fda-data-table thead{display:none}.fda-data-table tbody,.fda-data-table tr,.fda-data-table td{display:block}.fda-data-table__row{margin-bottom:var(--fda-space-4);border:1px solid var(--fda-table-border);border-radius:var(--fda-card-radius);padding:var(--fda-space-4)}.fda-data-table__cell{border-bottom:none;padding:var(--fda-space-2) 0}.fda-data-table__cell:before{content:attr(data-label);display:block;font-weight:var(--fda-font-semibold);color:var(--fda-text-secondary);font-size:var(--fda-text-sm);text-transform:uppercase;letter-spacing:.05em;margin-bottom:var(--fda-space-1)}}.fda-autocomplete,.fda-autocomplete__input-wrap{position:relative}.fda-autocomplete__input{width:100%;padding:var(--fda-space-3) var(--fda-space-4);font-size:var(--fda-text-xl);font-family:inherit;border:2px solid var(--fda-input-border);border-radius:var(--fda-input-radius);background:var(--fda-input-bg);color:var(--fda-text-primary);transition:border-color var(--fda-duration-normal) var(--fda-ease),box-shadow var(--fda-duration-normal) var(--fda-ease)}.fda-autocomplete__input:focus{outline:none;border-color:var(--fda-input-focus-border);box-shadow:var(--fda-input-focus-ring)}.fda-autocomplete__dropdown{position:absolute;top:100%;left:0;right:0;background:var(--fda-surface-primary);border:1px solid var(--fda-border-default);border-top:none;border-radius:0 0 var(--fda-radius-lg) var(--fda-radius-lg);box-shadow:var(--fda-shadow-md);z-index:100;max-height:300px;overflow-y:auto}.fda-autocomplete__item{display:flex;justify-content:space-between;align-items:center;padding:var(--fda-space-3) var(--fda-space-4);cursor:pointer;border-bottom:1px solid var(--fda-border-default);transition:background var(--fda-duration-fast) var(--fda-ease)}.fda-autocomplete__item:last-child{border-bottom:none}.fda-autocomplete__item:hover,.fda-autocomplete__item--active{background:var(--fda-interactive-hover)}.fda-autocomplete__item--empty{color:var(--fda-text-tertiary);cursor:default;font-size:var(--fda-text-md)}.fda-autocomplete__item--empty:hover{background:transparent}.fda-autocomplete__item-label{font-weight:var(--fda-font-medium);color:var(--fda-text-primary)}.fda-autocomplete__item-subtitle{font-size:var(--fda-text-md);color:var(--fda-text-tertiary);margin-left:var(--fda-space-4);flex-shrink:0}.fda-autocomplete__selected{display:flex;flex-wrap:wrap;gap:var(--fda-space-2);margin-bottom:var(--fda-space-3)}.fda-autocomplete__selected:empty{display:none}.fda-autocomplete__tag{display:inline-flex;align-items:center;gap:var(--fda-space-2);padding:var(--fda-space-1) var(--fda-space-3);background:var(--fda-surface-accent);border:1px solid var(--fda-border-accent);border-radius:var(--fda-radius-full);font-size:var(--fda-text-md);font-weight:var(--fda-font-medium);color:var(--fda-text-link)}.fda-autocomplete__tag-remove{background:none;border:none;cursor:pointer;font-size:var(--fda-text-3xl);line-height:1;color:var(--fda-text-tertiary);padding:0}.fda-autocomplete__tag-remove:hover{color:var(--fda-risk-red)}.fda-modal__overlay{position:fixed;inset:0;background:var(--fda-surface-overlay);display:flex;align-items:center;justify-content:center;z-index:9999;padding:var(--fda-space-4)}.fda-modal__dialog{background:var(--fda-surface-primary);border-radius:var(--fda-radius-xl);box-shadow:var(--fda-shadow-lg);max-width:480px;width:100%;max-height:90vh;overflow-y:auto;outline:none}.fda-modal__header{display:flex;justify-content:space-between;align-items:center;padding:var(--fda-space-5) var(--fda-space-6);border-bottom:1px solid var(--fda-border-default)}.fda-modal__title{font-size:var(--fda-text-2xl);font-weight:var(--fda-font-semibold);color:var(--fda-text-primary);margin:0}.fda-modal__close{background:none;border:none;font-size:var(--fda-text-4xl);color:var(--fda-text-tertiary);cursor:pointer;padding:var(--fda-space-1);line-height:1}.fda-modal__close:hover{color:var(--fda-text-primary)}.fda-modal__body{padding:var(--fda-space-6)}.fda-risk-gauge{text-align:center;padding:var(--fda-space-4)}.fda-risk-gauge__score{font-size:2.5rem;font-weight:var(--fda-font-bold);line-height:1;margin-bottom:var(--fda-space-2)}.fda-risk-gauge__score--red{color:var(--fda-risk-red)}.fda-risk-gauge__score--yellow{color:var(--fda-risk-yellow)}.fda-risk-gauge__score--green{color:var(--fda-risk-green)}.fda-risk-gauge__score--gray{color:var(--fda-risk-gray)}.fda-risk-gauge__label{font-size:var(--fda-text-md);font-weight:var(--fda-font-semibold);margin-bottom:var(--fda-space-1)}.fda-risk-gauge__detail{font-size:var(--fda-text-sm);color:var(--fda-text-tertiary)}.fda-timeline{padding:var(--fda-space-4) 0}.fda-timeline__group{margin-bottom:var(--fda-space-6)}.fda-timeline__year{font-size:var(--fda-text-md);font-weight:var(--fda-font-bold);color:var(--fda-text-primary);text-transform:uppercase;letter-spacing:.05em;border-bottom:2px solid var(--fda-border-default);padding-bottom:var(--fda-space-2);margin-bottom:var(--fda-space-3)}.fda-timeline__item{display:flex;align-items:flex-start;gap:var(--fda-space-3);padding:var(--fda-space-3) 0;border-bottom:1px solid var(--fda-gray-100);transition:background var(--fda-duration-fast) var(--fda-ease)}.fda-timeline__item:last-child{border-bottom:none}.fda-timeline__item:hover{background:var(--fda-surface-secondary);margin:0 calc(-1 * var(--fda-space-4));padding-left:var(--fda-space-4);padding-right:var(--fda-space-4)}.fda-timeline__dot{width:10px;height:10px;border-radius:50%;margin-top:var(--fda-space-2);flex-shrink:0}.fda-timeline__dot--483{background:var(--fda-type-483)}.fda-timeline__dot--wl{background:var(--fda-type-wl)}.fda-timeline__dot--recall{background:var(--fda-type-recall)}.fda-timeline__content{flex:1;min-width:0}.fda-timeline__header{display:flex;align-items:center;gap:var(--fda-space-2);margin-bottom:var(--fda-space-1)}.fda-timeline__date{font-size:var(--fda-text-sm);color:var(--fda-text-tertiary)}.fda-timeline__detail{font-size:var(--fda-text-md);color:var(--fda-text-secondary);line-height:1.5}.fda-loading{position:relative;min-height:120px}.fda-skeleton{position:absolute;inset:0;display:flex;align-items:center;justify-content:center;background:#ffffffd9;z-index:10;border-radius:8px}.fda-skeleton:after{content:"";width:32px;height:32px;border:3px solid #E5E7EB;border-top-color:#3b82f6;border-radius:50%;animation:fda-spin .8s linear infinite}@keyframes fda-spin{to{transform:rotate(360deg)}}.fda-shimmer{background:linear-gradient(90deg,#f3f4f6 25%,#e5e7eb,#f3f4f6 75%);background-size:200% 100%;animation:fda-shimmer 1.5s ease-in-out infinite;border-radius:4px}@keyframes fda-shimmer{0%{background-position:200% 0}to{background-position:-200% 0}}.fda-error{text-align:center;padding:3rem 1.5rem}.fda-error__message{color:#dc2626;font-size:1rem;font-weight:500;margin-bottom:.5rem}.fda-error__detail{color:#6b7280;font-size:.875rem;line-height:1.6;margin-bottom:1rem}.fda-error__retry{padding:.5rem 1.25rem;background:#1f3a5f;color:#fff;border:none;border-radius:5px;cursor:pointer;font-size:.875rem;font-family:inherit;transition:background .15s}.fda-error__retry:hover{background:#274b7a}.fda-error__retry:focus-visible{outline:2px solid #3B82F6;outline-offset:2px}.fda-sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}